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Drug Information: Omeprazole
Indications and Usage
Omeprazole is a proton pump inhibitor (PPI) indicated for the:
- Treatment of active duodenal ulcer in adults
- Eradication of Helicobacter pylori to reduce the risk of duodenal ulcer recurrence in adults
- Treatment of active benign gastric ulcer in adults
- Treatment of symptomatic gastroesophageal reflux disease (GERD) in patients 2 years of age and older
- Maintenance of healing of EE due to acid-mediated GERD in patients 2 years of age and older
- Pathologic hypersecretory conditions in adults
Dosage and Administration
Escitalopram tablets, USP should generally be administered once daily, morning or evening with or without food
Adolescents - Initial: 10 mg once daily; Recommended: 10 mg once daily; Maximum: 20 mg once daily;
Adults - Initial: 10 mg once daily; Recommended: 10 mg once daily; Maximum: 20 mg once daily;
Dosage Forms and Strengths
- 10 MG Capsules
- 20 MG Capsules
- 40 MG Capsules
Patients with known hypersensitivity to substituted benzimidazoles or any component of the formulation.
Patients receiving rilpivirine-containing products.
Refer to the Contraindications section of the prescribing information for clarithromycin and amoxicillin, when administered in combination with omeprazole.
Warnings and Precautions
- Gastric Malignancy: In adults, symptomatic response does not preclude the presence of gastric malignancy. Consider additional follow-up and diagnostic testing.
- Acute Interstitial Nephritis: Observed in patients taking PPIs.
- Clostridium difficile-Associated Diarrhea: PPI therapy may be associated with increased risk.
- Bone Fracture: Long-term and multiple daily dose PPI therapy may be associated with an increased risk for osteoporosis-related fractures of the hip, wrist or spine.
- Cutaneous and Systemic Lupus Erythematosus: Mostly cutaneous; new onset or exacerbation of existing disease; discontinue omeprazole and refer to specialist for evaluation
- Interaction with Clopidogrel: Avoid concomitant use of omeprazole
- Cyanocobalamin (Vitamin B-12) Deficiency: Daily long-term use (e.g., longer than 3 years) may lead to malabsorption or a deficiency of cyanocobalamin.
- Hypomagnesemia: Reported rarely with prolonged treatment with PPIs.
- Interaction with St. John’s Wort or Rifampin: Avoid concomitant use of omeprazole.
- Interactions with Diagnostic Investigations for Neuroendocrine Tumors: Increased Chromogranin A (CgA) levels may interfere with diagnostic investigations for neuroendocrine tumors; temporarily stop omeprazole at least 14 days before assessing CgA levels.
- Interaction with Methotrexate: Concomitant use with PPIs may elevate and/or prolong serum concentrations of methotrexate and/or its metabolite, possibly leading to toxicity. With high dose methotrexate administration, consider a temporary withdrawal of omeprazole
Adults: Most common adverse reactions in adults (incidence ≥2%) are: Headache, abdominal pain, nausea, diarrhea, vomiting, and flatulence
Pediatric patients (2 to 16 years of age):Safety profile similar to that in adults, except that respiratory system events and fever were the most frequently reported reactions in pediatric studies.
See full prescribing information for a list of clinically important drug interactions.